Publications

  1. Bender, K. J., Wang, Y., Zhai, C.Y., Saenz, Z., Wang, A.A., Neumann, E. K., “Spatial lipidomics of
    undecalcified fresh-frozen spines”, Analytical Chemistry, Submitted.
  2. Brower, R. S., Wuille Bille, B., Perryman, J. T., Yao, L., Gomez, R., Neumann, E. K., McCrory, C.,
    Velázquez, J. M. “Enhancing the Microenvironments of Carbon Supports Through Fluoropolymer
    Encapsulation of Trace Metallic Pb for CO2R to Oxalate”, submitted.
  3. Stevens, N., Martinez, J., Brown, V., Domanico, M., Neumann, E. K., van Winkle, L., Fiehn, O.
    “Location matters: mass spectrometry imaging analysis of lung responses to inhaled toxicant
    exposure”, PNAS Nexus, under review.
  4. Sharman, K., Patterson, N. H., Migas, L. G., Neumann, E. K., Allen, J. L., Gibson-Corley, K. N.,
    Spraggins, J. M., Van de Plas, R., Skaar, E. P., Caprioli, R. M. “MALDI IMS-Derived Molecular
    Contour Maps: Augmenting Histology Whole-Slide Images”, Journal of the American Society for Mass Spectrometry, accepted.
  5. Kraemer, Y., Ghiazza, C., Ragan, A. N., Ni, S., Lutz, S., Neumann, E. K., Fettinger, J. C., Nöthling,
    N., Goddard, R., Cornella, J., Pitts, C. R. “Strain-Release Pentafluorosulfanylation and
    Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight”, Angewandte
    Chemi, accepted.
  6. Ellen M. Quardokus, Diane C. Saunders, Elizabeth McDonough, John W. Hickey, Christopher
    Werlein, Christine Surrette, Presha Rajbhandari, Anna Martinez Casals, Hua Tian, Lisa Lowery,
    Elizabeth K. Neumann, Frida Björklund, Taruna Neelakantan, Josh Croteau, Anne E. Wiblin,
    Jeremy Fisher, April J. Livengood, Karen G Dowell, Jonathan C. Silverstein, Jeffrey M.
    Spraggins11,12,20,21, Gloria S. Pryhuber22, Gail Deutsch23, Fiona Ginty, Garry P. Nolan5, Simon
    Melov24, Danny Jonigk, Michael A. Caldwell, Ioannis S. Vlachos, Werner Muller, Nils Gehlenborg,Taruna Neelakantan, Brent R. Stockwell, Emma Lundberg, Michael P. Snyder, Ronald N. Germain, Jeannie M. Camarillo, Neil L. Kelleher, Katy Börner, Andrea J. Radtke “Organ Mapping Antibody Panels (OMAPs): A community resource for standardized multiplexed tissue imaging”, accepted, Nature Methods.
  7. Neumann, E. K., Patterson, N. H., Tideman, L., Sharman, K., Migas, L., Allen, J. L., Yang, H.,
    Anderson, D. M., Gutierrez, D., Brewer, M., deCaestecker, M. P., Harris, R., Fogo, A., Van de Plas,
    R., Caprioli, R. M., Spraggins, J. M. “A multiscale atlas of the molecular and cellular architecture of
    the human kidney”, under review, Nature.
  8. Rivera, E. S., Weiss, A., Migas, L., Freiberg, J. A., Djambazova, K. V., Neumann, E. K., Van de
    Plas, R., Spraggins, J. M., Skaar, E. P., Caprioli, R. M. “Imaging Mass Spectrometry Reveals Complex
    Lipid Distributions Across Staphylococcus aureus Biofilm Layers”, accepted.
  9. Sharman, K., Patterson, N. H., Neumann, E. K., Weiss, A., Gutierrez, D. B., Van de Plas, R., Skaar,
    E. P., Caprioli, R. M., Spraggins, J. M. “Analyzing High-Dimensional Spatially Targeted Proteomics
    Data During Staphylococcus aureus Infection”, accepted.
  10. Good, C. J., Neumann, E. K., Butrico, C. E., Cassat, J. E., Caprioli, R. M. Spraggins, J. M.,
    “MALDI Imaging Mass Spectrometry of Cell Types within Fresh-Frozen Bone Tissue”, Analytical
    Chemistry, 2022, 94, 7, 3165–3172.
  11. Su, P., McGee, J.P., Durbin, K. R., Hollas, M. A. R., Yang, M., Neumann, E.K., Allen, J. L.,
    Drown, B. S., Butun, F. A., Greer, J. B., Early, B. P., Fellers, R. T., Spraggins, J. M., Laskin, J.,
    Camarillo, J. M., Kafader, J. O., Kelleher, N. L. “Direct Imaging and Identification of Proteoforms
    up to 70 kDa from Human Kidney”, accepted.
  12. Neumann, E. K., Sharman, K., Patterson, N. H., Weiss, A., Allen, J. L., Sheldon, J. R., Van der
    Plas, R., Caprioli, R. M., Skaar, Spraggins, J. M. “Deciphering Host Immune Responses with MALDI
    IMS and CODEX Immunofluorescence”, under review.
  13. Richardson, L. T., Neumann, E. K., Caprioli, R. M., Spraggins, J. M., Solouki, T. S. “Referenced
    Kendrick Mass Defect Annotation and Class-Based Filtering of Imaging MS Lipidomics
    Experiments”, accepted, Analytical Chemistry.
  14. Patterson, N. H., Neumann, E. K., Sharman, K., Anderson, D. M., Allen, J. L., Brewer, M., Harris,
    R., deCaestecker, M. P., Fogo, A., Caprioli, R. M., Van de Plas, R., Spraggins, J. M.
    “Autofluorescence microscopy as a label free tool for renal histology and glomerular segmentation”,
    under review.
  15. Neumann, E. K., Bhaduri, A., Kriegstein, A. R., Sweedler, J. V. “Identification of lipid
    heterogeneity and diversity in the developing human brain”, JACS Au, 2021, 1, 12, 2261–2270.
  16. Neumann, E. K., Rivera, E. S., Patterson, N. H., Allen, J. L., Brewer, M.., deCaestecker, M. P.,
    Fogo, A. G., Caprioli, R. M., Spraggins, J. M. “Highly Multiplexed Immunofluorescence of the
    Human Kidney using Co-Detection by Indexing (CODEX).”, Kidney International, 2022, 101(1), 137-
    143. (10.1016/j.kint.2021.08.033).
  17. Neumann, E. K., Hickey, J. W., Radtke, A. J., Camarillo, J. M., Beuschel, R. T., McDonough, E.,
    Hatler, J., Wilbin, A., Fisher, J., Croteau, J., Sood, A., Caprioli, R. M., Angelo, M., Nolan, G., Hewitt,
    S. H., Germain, R. N., Spraggins, J. M., Lundberg, E., Snyder, M. P., Kelleher, N. L., Saka, S. K.
    “Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-
    based imaging”, Nature Methods, 2022, 19, 284–295.
  18. Neumann, E. K., Patterson, N. H., Allen, J. L., Migas, L., Yang, H., Brewer, M., Anderson, D. M.,
    Gutierrez, D., Harris, R., deCaestecker, M. P., Fogo, A., Van de Plas, R., Caprioli, R. M., Spraggins, J.
    M. “Protocol for multimodal analysis of human kidney tissue by imaging MS and CODEX
    multiplexed immunofluorescence”, Star Protocols, 2021, 2(3):100747.
  19. Neumann, E. K.; Djambazova, K. V.; Caprioli, R. M.; Spraggins, J. M. “Multimodal Imaging Mass
    Spectrometry: Next Generation Molecular Mapping in Biology and Medicine.” Journal of the American
    Society for Mass Spectrometry, 2020, 31(12), 2401-2415.
  20. Rivera, E. S.; Djambazova, K. V.; Neumann, E. K.; Caprioli, R. M.; Spraggins, J. M. “Integrating
    ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief
    review and perspective.” Journal of Mass Spectrometry, 2020, 55(12). e4614- e4629.
  21. Djambazova, K. V.; Klein, D. R.; Migas, L. G.; Neumann, E. K.; Rivera, E. S.; Van de Plas, R.;
    Caprioli, R. M.; Spraggins, J. M. “Resolving the Complexity of Spatial Lipidomics Using MALDI
    TIMS Imaging Mass Spectrometry.” Analytical Chemistry 2019, 92(19), 13290-13279.22.
  22. Neumann, E. K.; Migas, L. G.; Allen, J. L.; Van de Plas, R.; Caprioli, R. M.; Spraggins, J. M. “Spatial
    Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass
    Spectrometry.” Analytical Chemistry 2020, 92(19), 13084-13091.
  23. Snyder, M.P.; Lin. S., Posgai, A.; et al.; Neumann, E. K.; et al. “The Human Body at Cellular
    Resolution: the NIH Human Biomolecular Atlas Program.” Nature 2019, 574, 187-192.
  24. Perry, W. J.; Patterson, N. H.; Prentice, B. M.; Neumann, E. K.; Caprioli, R. M.; Spraggins, J. M.
    “Varying Lipidomics Sensitivities when Employing MALDI Matrices for Imaging Mass
    Spectrometry.” Journal of Mass Spectrometry 2020, 55(4), e4491 .
  25. Spraggins, J. M.; Djambazova, K. V.; Rivera, E. S.; Migas, L. G.; Neumann, E. K.; Fuetterer, A.;
    Suetering, J.; Goedecke, N.; Ly, A.; Van de Plas, R.; Caprioli, R. M. “High-Performance Molecular
    Imaging with MALDI Trapped Ion-Mobility Time-of_Flight (timsTOF) Mass Spectrometry.”
    Analytical Chemistry 2019, 91(22), 14552-14560.
  26. Ta, K.; Zhang, R.; Shin, M.; Rooney, R. T.; Neumann, E. K.; Gewirth, A. A. “Understanding Ca
    electrodeposition and speciation processes in nonaqueous electrolytes for next-generation Ca-ion
    batteries.” ACS Applied Materials & Interfaces, 2019, 11(24), 21536-21542.
  27. Neumann, E. K.; Ellis, J. F.; Triplett, A. E.; Rubakhin, S. S.; Sweedler, J. V. “Lipid analysis of
    thirty-thousand individual brain cells using high-resolution mass spectrometry.” 2019, 91(12), 7871-
    7878.
  28. Neumann, E. K.; Sanghamitra, D.; Comi, T. J.; Rubakhin, S. S.; Gillette, M. U.; Bhargava, R.;
    Sweedler, J. V. “Single cell MALDI mass spectrometry hyphenated to stimulated Raman scattering
    microscopy for enhanced chemical coverage.” Under revision.
  29. Neumann, E. K.; Do, T. D.; Comi, T. J.; Sweedler, J. V. “Exploring the Fundamental Structures of
    Life: Nontargeted, Chemical Analysis of Single Cells and Subcellular Structures.” Angewandte Chemie
    2018, 58(28), 9348-9364.
  30. Neumann, E. K.; Comi, T. J.; Rubakhin, S. S.; Sweedler, J. V. “Single Cell MALDI-MS supervised
    by immunocytochemical classification.” Angewandte Chemie 2019, 58(18), 5910-5914.
  31. Li, B.; Neumann, K. E.; Ge, J.; Gao, W.; Yang, H.; Li, P.; Sweedler, J. V. “Interrogation of Spatial
    Metabolome of Ginkgo biloba with High-resolution MALDI and LDI Mass Spectrometry Imaging.”
    Plant, Cell & Environment 2018, 41(11), 2693-270.
  32. Neumann, E. K.; Comi, T. J.; Spegazzini, N.; Mitchell, J. W.; Rubakhin, S. S.; Bhargava, R.; Gillette,
    M. U.; Sweedler, J. V. “Multimodal Chemical Analysis of the Brain by High Resolution Mass Spec-
    trometry and Infrared Spectroscopic Imaging.” Analytical Chemistry 2018, 90(11), 11572-11580.
  33. Dunham, S. J. B.; Neumann, E. K.; Lanni, E. J.; Ong, T.; Sweedler, J. V. “Biomarker Discovery
    with Mass Spectrometry Imaging and Profiling.” Proteomics: the Catalyst to Biological Discovery 2019.
  34. Do, T. D.; Ellis, J. F.; Neumann, E. K.; Comi, T. J.; Tillmaand, E. G.; Lenhart, A. E.; Rubakhin, S.
    S.; Sweedler, J. V. “Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to
    Profile Lipids, Peptides and Proteins.” ChemPhysChem 2018, 19(10).
  35. Comi, T. J.; Neumann, E. K.; Do, T.; Sweedler, J. V. “microMS: A Python Platform for Image-
    guided Mass Spectrometry Profiling.” Journal of the American Society for Mass Spectrometry 2017, 28, 28,1919-1928.
  36. Harper, B.; Neumann, E. K.; Stow, S. M.; May, J. C.; McLean, J. A.; Solouki, T. “Calculating
    Accurate Collision Cross-sections of Ion Mobility Unresolved Isomers Using Tandem Mass
    Spectrometry and Chemometric Deconvolution.” Analytica Chimica Acta 2016, 939, 64-72.
  37. Harper, B.; Neumann, E. K.; Solouki, T. “DNA Oligonucleotide Fragment Ion Rearrangements
    Upon Collision-induced Dissociation.” Journal of the American Society for Mass Spectrometry 2015, 26(8),
    1404-1413.
  38. Pope, W. H.; Bowman, C. A.; Russell, D. A.; Jacobs-Sera, D.; Asai, D. J.; Cresawn, S. G.; Jacobs, W.
    R. Jr.; Hendrix, R. W.; Lawrence, J. G.; Hatfull, G. F.; Science Education Alliance Phage Hunters
    Advancing Genomics and Evolutionary Science; Phage Hunters Integrating Research and
    Education; and Mycobacterial Genetics Course. “Dramatic Variation in Phage Genome Structures
    Revealed by Whole Genome comparisons.” eLife 2015,4, e06416.